# Estimating Probability of Causation (Assigned Share*)

## General Equation

The probability of causation (PC) is calculated as the risk of cancer attributable to radiation exposure (RadRisk) divided by the sum of the baseline risk of cancer to the general population (BasRisk) plus the risk attributable to the radiation exposure, multiplied by 100 percent, as follows:

This calculation provides a percentage estimate between 0 and 100 percent, where 0 would mean 0 likelihood that radiation caused the cancer and 100 would mean 100 percent certainty that radiation caused the cancer.

## Equation used in NIH-IREP

Probability of Causation (Assigned Share) = Excess Relative Risk Relative Risk x 100%

Excess Relative Risk (ERR) = proportion of Relative Risk (RR) due solely to radiation exposure (ERR=RR-1)

Relative Risk (RR) = ratio of the total risk from exposure divided by risk due to background alone

## Equations to Estimate Excess Relative Risk (ERR)

Total Excess Relative Risk = Σ
Exposure
period
( Excess Relative Risk (sources other than radon) + Excess Relative Risk (radon source) ) x User Defined Additional Uncertainty